If you have taken high school biology, you probably learned about the cell division: an important process in all life forms is officially called mitosis. For more than one hundred years, students have learned that during mitosis, a original cell becomes circular before dividing two daughter cells of the same size and size. A new study, however, can re -write many biology textbooks.
Researchers revealed that mitosis does not always feature cell rounding (when a original cell becomes circular), which means that resulting daughter cells are not always symmetrical, nor do they do the same task. Their work is wide in one Study Posted on Thursday in Journal Science, and diseases such as cancer have significant implications for understanding cell division.
“Students learn that when a cell is divided, it will generate a uniform spherical shape. Our study, however, shows that in real living organisms, it is not as simple,” the co-author of the study, Shane Herbert and a researcher of biology, medicine and health of the University of Manchester, said at a university, said in a university. statement,
In the new study, researchers observed the blood vessel formation in the zebrafish embryo. The growth of new vessels consists of slow -moving cells under the leadership of the same rapidly running cell. When the lead cell passes through mitosis, it did not occur or experience. The asymmetrical division allowed it to make two different cells: a slow-moving cell and a fast-moving cell to take the lead in the original cell space. Previously, scientists were mainly associated with asymmetric cell division with special cells called stem cells.
“Using a transparent 1-day old zebrafish embryo allows us to study a dynamic process such as a cell division inside a living organism,” Holi Lovegrove said the co-nominated writer of the study and a lecturer in cardiovascular sciences at the University of Manchester. “So we are able to make films of this fundamental cell behavior and reveal exciting new aspects in doing so how tissues grow.”
In addition, researchers said that the size of the original cell could determine that its division would be symmetrical or odd. For example, he saw that small and broad cells were more likely to be circular and divided into two identical daughter cells. Conversely, long and thin cells did not “round-up” and, as a result, divide oddly.
To examine this, Herbert, Lovegrove, and their colleagues manipulated the shape of human original cells via micropratering. “Micropiating allows us to generate a particularly shaped subtle patches of proteins, which can stick to the cells,” the co-author of the study explained by the author Georgia Hulms and a PostDoATARALREDARAL at the University of Manchester at the University of Manchester. “The cells will then move the size of the patch. This is why it allows us to change the shape of the cells and test how these size affect the later cell division.”
“Our research suggests whether a cell can originally direct the size of the cell before dividing the size, and significantly, if its daughters are symmetrical or asymmetric in both size and function,” said Herbert.
As a result, scientists may be able to generate cells with various tasks by controlling the size of their original cells one day. More broadly, their analysis shows that asymmetric partitions play an important role in the creation of various tissues and organs. The study also has significant implications for diseases such as cancer, in which asymmetrical partitions can cause various cell behavior associated with the progression of cancer.
Meanwhile, our views are with all students, parents and school administrators, who may soon have to spend an excessive amount on the updated textbooks.
